Regulation of neuronal L-type voltage-gated calcium channels by flurazepam and other positive allosteric GABA[subscript]A receptor modulators
نویسندگان
چکیده
..................................................................................................................... iii ACKNOWLEDGEMENTS ..............................................................................................v TABLE OF CONTENTS ............................................................................................... vii LIST OF TABLES .......................................................................................................... xii LIST OF FIGURES ....................................................................................................... xiii LIST OF ABBREVIATIONS .........................................................................................xv CHAPTER 1 INTRODUCTION ....................................................................................1 CHAPTER 2 LITERATURE REVIEW........................................................................7 2.1 Benzodiazepines and other positive allosteric GABAA receptor modulators ..........7 2.2 GABAA receptor structure and function ..................................................................8 2.3 Positive allosteric modulation of the GABAA receptor .........................................11 2.4 Additional sites of action GABAA receptor modulators ........................................15 2.5 Withdrawal from GABAA receptor modulators.....................................................18 2.6 The hippocampus and its role in drug dependence ................................................20 2.7 Hippocampal GABAergic network........................................................................24 2.8 Molecular substrates of drug dependence: Role of GABAA receptor dysfunction ...................................................................................................................25 2.9 Molecular substrates of drug dependence: Role of ionotropic glutamate receptors .......................................................................................................................32
منابع مشابه
Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors.
Benzodiazepines (BDZs) depress neuronal excitability via positive allosteric modulation of inhibitory GABA(A) receptors (GABA(A)R). BDZs and other positive GABA(A)R modulators, including barbiturates, ethanol, and neurosteroids, can also inhibit L-type voltage-gated calcium channels (L-VGCCs), which could contribute to reduced neuronal excitability. Because neuronal L-VGCC function is up-regula...
متن کاملCoregulation of ion channels by neurosteroids and phosphorylation.
This Perspective by Tasker is one of two discussing the regulation of ion channels by neurosteroids. Neurosteroids are steroids synthesized in the brain that act as allosteric modulators of ion-channel activity. The dual regulation of gamma-aminobutyric acid type A (GABA(A)) receptors and voltage-gated calcium channels by phosphorylation and neurosteroids is the focus of this Perspective.
متن کاملStructural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor.
Many clinically important drugs target ligand-gated ion channels; however, the mechanisms by which these drugs modulate channel function remain elusive. Benzodiazepines (BZDs), anesthetics, and barbiturates exert their CNS actions by binding to GABA(A) receptors and modulating their function. The structural mechanisms by which BZD binding is transduced to potentiation or inhibition of GABA-indu...
متن کاملThe role of L-type voltage-gated calcium channels in hippocampal CA1 neuron glutamate and GABA-A receptor-mediated synaptic plasticity following chronic benzodiazepine administration
متن کامل
Characterization of spontaneous network-driven synaptic activity in rat hippocampal slice cultures
A particular characteristic of the neonatal hippocampus is the presence of spontaneous network-driven oscillatory events, the so-called giant depolarizing potentials (GDPs). GDPs depend on the interplay between GABA and glutamate. Early in development, GABA, acting on GABAA receptors, depolarizes neuronal membranes via a Cl- efflux. Glutamate, via AMPA receptors, generates a positive feedback n...
متن کامل